UMEM Educational Pearls

Critical Post-Arrest Interventions

  • Critical interventions to optimize neurologic outcome in the post-cardiac arrest patient include optimizing hemodynamics, preventing lung injury, maintaining normal O2 and CO2 tensions, targeted temperature management, and treating the underlying cause of the arrest.
  • Current guidelines recommend the following:
    • Target MAP > 70 mm Hg with IVFs, vasopressors, and inotropes.
    • Use a low tidal volume strategy of 6 to 8 ml/kg predicted body weight.
    • Decrease FiO2 to maintain SpO2 94% to 97%.
    • Adjust RR to maintain PaCO2 35 to 45 mm Hg
    • Initiate TTM with the goal temperature between 32 to 36o C


Walker AC, Johnson NJ. Critical care of the post-cardiac arrest patient. Cardiol Clin. 2018; 36:419-428.