UMEM Educational Pearls

Category: Obstetrics & Gynecology

Title: Rhogam Basics

Keywords: Rhogam, Pregnancy (PubMed Search)

Posted: 2/9/2008 by Michael Bond, MD (Updated: 7/14/2024)
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  • Remember to administer Rhogam to any Rh negative mother that has the following conditions:
  • Pregnancy/delivery of an Rh-positive baby
  • Abortion/threatened abortion at any stage of gestation
  • Ectopic pregnancy
  • Antepartum fetal-maternal hemorrhage (suspected or proven) resulting from antepartum hemorrhage (e.g., placenta previa), amniocentesis, chorionic villus sampling, percutaneous umbilical blood sampling, other obstetrical manipulative procedure (e.g., version) or abdominal trauma
  • Transfusion of Rh incompatible blood or blood products (i.e.: platelets)


  • 300 mcg IM
  • Can give 50 mcg IM within 72 h of exposure of a therapeutic or spontaneous abortion if gestation age is 12 weeks or less. (Order as MICRhogam)
  • Additional doses of Rhogam may be necessary when the patient has been exposed to > 15 mL of Rh-positive red blood cells. This may be determined by use of qualitative or quantitative tests for fetal maternal hemnorrhage but generally will only occur during a full term delivery or if incompatible blood products are given.


Trivial Fact: Rhogam is Pregnancy Class C