Category: Pharmacology & Therapeutics
Keywords: anterior epistaxis, tranexamic acid, antifibrinolytic (PubMed Search)
Posted: 2/6/2014 by Ellen Lemkin, MD, PharmD
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Tranexamic Acid (TXA) topically applied was compared to anterior nasal packing in 216 patients with acute anterior epistaxis. Cotton pledgets (15 cm) soaked in injectable TXA (500 mg/5 ml) were inserted into the bleeding nostril and removed after bleeding had arrested. This was compared to standard anterior packing.
TXA Anterior packing
% pts bleeding stopped in 10 min: 71% 31.2%
Discharge after 2 hours 95.3% 6.4%
Rebleeding in 24 h hours 4.7% 11%
Satisfaction scores 8.5 4.4
Bottom line: topical tranexamic acid looks promising for control of uncomplicated anterior epistaxis.
Zahed R, Moharamzadeh P, AlizadeArasi S, Ghasemi A, Saeedi M. A new and rapid method for epistaxis treatment using injectable form of tranexamic acid topically: a randomized controlled trial. AJEM 2013 (31):1389-92.
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