Category: Pharmacology & Therapeutics
Keywords: anterior epistaxis, tranexamic acid, antifibrinolytic (PubMed Search)
Tranexamic Acid (TXA) topically applied was compared to anterior nasal packing in 216 patients with acute anterior epistaxis. Cotton pledgets (15 cm) soaked in injectable TXA (500 mg/5 ml) were inserted into the bleeding nostril and removed after bleeding had arrested. This was compared to standard anterior packing.
TXA Anterior packing
% pts bleeding stopped in 10 min: 71% 31.2%
Discharge after 2 hours 95.3% 6.4%
Rebleeding in 24 h hours 4.7% 11%
Satisfaction scores 8.5 4.4
Bottom line: topical tranexamic acid looks promising for control of uncomplicated anterior epistaxis.
Zahed R, Moharamzadeh P, AlizadeArasi S, Ghasemi A, Saeedi M. A new and rapid method for epistaxis treatment using injectable form of tranexamic acid topically: a randomized controlled trial. AJEM 2013 (31):1389-92.