UMEM Educational Pearls

Title: Kawasaki Disease

Category: Cardiology

Keywords: Kawasaki Disease, Mucocutaneous lymph node syndrome (PubMed Search)

Posted: 12/2/2012 by Semhar Tewelde, MD (Updated: 11/12/2024)
Click here to contact Semhar Tewelde, MD

 

Kawasaki disease (KD) is the leading cause of acquired heart disease in North American & Japanese children
Children w/KD should undergo a 2-D echocardiogram and electrocardiogram
In the acute phase, the myocardium, pericardium, endocardium, valves, conduction system, and coronary arteries may all be involved
KD shock syndrome is a cardiovascular manifestation that presents with hypotension, LV systolic dysfunction, coronary artery aneurysm, and a shocklike state
AHA recommends KD tx w/a single dose of 2 g/kg of IVIG infused over 12 hours plus high-dose aspirin at a dose of 80 to 100 mg/kg per day in 4 divided doses
More than 50% of coronary artery aneurysms regress within the first 2 years of onset 
Regression is associated with marked thickening of the intima, which  may later stimulate atherosclerosis with a risk for ischemic heart disease

References

Scuccimarri R. Kawasaki Disease. Pediatric Clin N Am 59(2012)425-445