UMEM Educational Pearls

Ventilator Pearls for H1N1 Influenza Virus

  • As the spring/summer travel season begins, it is predicted that we will see additional cases of H1N1
  • The most common presentation requiring ICU admission to date has been a viral pneumonitis
  • As highlighted in previous pearls, the hallmark of disease has been refractory hypoxemia requiring mechanical ventilation in about 85% of patients.
  • Current recommendations for H1N1 respiratory failure:
    • Consider early intubation
    • Noninvasive ventilation has been unsuccessful in most and should generally be avoided
    • Low tidal volume settings (6 ml/kg) with PEEP based on FiO2 to maintain SpO2 > 88% and plateau pressure < 35 cm H2O
    • Although there is no proven mortality benefit to rescue therapies such as recruitment maneuvers, neuromuscular blockade, and prone ventilation, these can be considered in discussion with your intensivist.


Ramsey CD, Funk D, Miller RR, Kumar A. Ventilator management for hypoxemic respiratory failure attributable to H1N1 novel swing origin influenza virus. Crit Care Med 2010; 38(Suppl):e58-65.