Nikolsky's sign is positive when slight rubbing of the skin results in exfoliation of the skin's outermost layer. The more technical term is acantholysis which is the loss of the normal adhesion of the epithelial skin cells which allows for this sloughing.
Seen in:
Toxic Epidermal Necrolysis
Pemphigus vulgaris
Scalled Skin Syndrome
Bullous impetigo
Epidermolysis bullosa
Often helpful to differentiate pemphigus vulgaris from bullous pemphigoid. The sign is usually absent in bullous pemphigoid. Just be careful with how much testing you are doing as this can be very painful to the patient.
